If you are in a major bout of depression, you may feel like you are beyond help. However, depression CAN be treated and managed. If your state of gloom/sadness persists more than two weeks, you find that you cannot get out of bed, you are increasingly isolated from family and friends, and you have lost any sense of enjoyment or interest in your usual activities, call your doctor right away. Also, if you find yourself ruminating about death and the meaningless of life and you are considering suicide, SEEK HELP IMMEDIATELY. There is help available and things will and do get better.